Research Use Only·Third-Party Analytical Testing·COA Available·Authorized Researchers OnlyResearch Use Only · COA Available · Authorized Researchers
peptide-solutions
Senolytic D-retro-inverso peptide for cellular senescence research
Research Compound
Manufactured under strict quality control protocols with full analytical testing. Certificate of Analysis (COA) available upon request.
FOX04-DRI is a D-retro-inverso peptide designed to selectively eliminate senescent cells by disrupting the FOXO4–p53 interaction that normally protects them from apoptosis. Introduced in the 2017 Baar et al. Cell publication as a proof-of-concept senolytic, it has become a workhorse reagent in cellular senescence and aging biology research.
Compound Specifications
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Amount per vial: 5mg
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Scientific Documentation
Detailed research information, pharmacological profile, and handling specifications
FOXO4 is sharply upregulated in senescent cells where it scaffolds p53 in the nucleus to prevent the apoptotic program. FOX04-DRI competitively displaces p53 from FOXO4, allowing p53 to relocalize to the mitochondria and trigger selective apoptosis of senescent cells while sparing healthy proliferating and quiescent populations.
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This product is intended strictly for laboratory and research purposes only. Not for human or veterinary use. Not intended to diagnose, treat, cure, or prevent any disease. By purchasing, you confirm that you are an authorized researcher or institution and that this product will be used solely for legitimate research purposes in compliance with all applicable laws and regulations.
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