peptide-solutions

PE-228

Sortilin-derived neuropeptide for TREK-1 channel research

Research Compound

Manufactured under strict quality control protocols with full analytical testing. Certificate of Analysis (COA) available upon request.

Purity: >98%Form: LyophilizedStorage: -20°CGrade: Research

New

PE-228 (also referenced in the literature as PE 22-28) is a short sortilin-derived peptide studied as a TREK-1 potassium channel inhibitor. The TREK-1 pathway has been linked to mood regulation and neuronal excitability, making PE-228 a research tool in neuropharmacology and antidepressant-mechanism studies.

Compound Specifications

Purity Level>98%

Physical FormLyophilized powder (10mg/vial)

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$75USD

Amount per vial: 10mg

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Research-Grade

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Scientific Documentation

Research Reference

Detailed research information, pharmacological profile, and handling specifications

Mechanism of Action

PE-228 is derived from the propeptide of sortilin and inhibits the TREK-1 (KCNK2) two-pore-domain potassium channel. TREK-1 inhibition in cortical and serotonergic circuits has been linked to fast-onset antidepressant-like effects in rodent models, paralleling the mechanism initially identified with the parent peptide spadin.

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Research Use Only Disclaimer

This product is intended strictly for laboratory and research purposes only. Not for human or veterinary use. Not intended to diagnose, treat, cure, or prevent any disease. By purchasing, you confirm that you are an authorized researcher or institution and that this product will be used solely for legitimate research purposes in compliance with all applicable laws and regulations.